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Small Molecule Control of Intracellular Protein Levels Through Modulation of the Ubiquitin Proteasome System
Traditionally, biological probes and drugs have targeted the activities of proteins (such as enzymes and receptors) that can be easily controlled by small molecules. The remaining majority of the proteome has been deemed “undruggable”. By using small molecule modulators of the ubiquitin proteasome,...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4348030/ https://ncbi.nlm.nih.gov/pubmed/24459094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201307761 |
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