Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems

Targeting the ubiquitin–proteasome system (UPS) and ubiquitin-like signalling systems (UBL) has been considered a promising therapeutic strategy to treat cancer, neurodegenerative and immunological disorders. There have been multiple efforts recently to identify novel compounds that efficiently modu...

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Vydáno v:Oncotarget
Hlavní autoři: Amelio, Ivano, Landré, Vivien, Knight, Richard A., Lisitsa, Andrey, Melino, Gerry, Antonov, Alexey V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496386/
https://ncbi.nlm.nih.gov/pubmed/25991664
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