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A Bidirectional System for the Dynamic Small Molecule Control of Intracellular Fusion Proteins

Small molecule control of intracellular protein levels allows temporal and dose-dependent regulation of protein function. Recently, we developed a method to degrade proteins fused to a mutant dehalogenase (HaloTag2) using small molecule hydrophobic tags (HyTs). Here, we introduce a complementary met...

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Detalhes bibliográficos
Main Authors: Neklesa, Taavi K., Noblin, Devin J., Kuzin, Alexander P., Lew, Scott, Seetharaman, Jayaraman, Acton, Thomas B., Kornhaber, Gregory J., Xiao, Rong, Montelione, Gaetano Thomas, Tong, Liang, Crews, Craig M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113957/
https://ncbi.nlm.nih.gov/pubmed/23978068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400569k
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