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TRAF6 promotes TGFβ-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFβ type I receptor

Transforming growth factor β (TGFβ) can act either as a tumor promoter or a tumor suppressor in a context-dependent manner. High levels of TGFβ are found in prostate cancer tissues and correlate with poor patient prognosis. We recently identified a novel TGFβ-regulated signaling cascade in which TGF...

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Bibliografski detalji
Izdano u:Cell Cycle
Glavni autori: Sundar, Reshma, Gudey, Shyam Kumar, Heldin, Carl-Henrik, Landström, Marene
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347693/
https://ncbi.nlm.nih.gov/pubmed/25622187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.990302
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