Polyubiquitination of Transforming Growth Factor β (TGFβ)-associated Kinase 1 Mediates Nuclear Factor-κB Activation in Response to Different Inflammatory Stimuli

The transcription factor nuclear factor κB (NF-κB) plays a central role in regulating inflammation in response to several external signals. The TGFβ-associated kinase 1 (TAK1) is an upstream regulator of NF-κB signaling. In TGFβ-stimulated cells, TAK1 undergoes Lys-63-linked polyubiquitination at Ly...

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Hlavní autoři: Hamidi, Anahita, von Bulow, Verena, Hamidi, Rosita, Winssinger, Nicolas, Barluenga, Sofia, Heldin, Carl-Henrik, Landström, Marene
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249064/
https://ncbi.nlm.nih.gov/pubmed/22069318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.285122
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