TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

Transforming growth factor β (TGFβ) is a pluripotent cytokine promoting epithelial cell plasticity during morphogenesis and tumour progression. TGFβ binding to type II and type I serine/threonine kinase receptors (TβRII and TβRI) causes activation of different intracellular signaling pathways. TβRI...

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Detalhes bibliográficos
Main Authors: Mu, Yabing, Sundar, Reshma, Thakur, Noopur, Ekman, Maria, Gudey, Shyam Kumar, Yakymovych, Mariya, Hermansson, Annika, Dimitriou, Helen, Bengoechea-Alonso, Maria Teresa, Ericsson, Johan, Heldin, Carl-Henrik, Landström, Marene
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113296/
https://ncbi.nlm.nih.gov/pubmed/21629263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1332
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