Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

Chronic graft-versus-host disease (cGVHD) is a life-threatening impediment to allogeneic hematopoietic stem cell transplantation, and current therapies do not completely prevent and/or treat cGVHD. CD4(+) T cells and B cells mediate cGVHD; therefore, targeting these populations may inhibit cGVHD pat...

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Publicado en:J Clin Invest
Main Authors: Dubovsky, Jason A., Flynn, Ryan, Du, Jing, Harrington, Bonnie K., Zhong, Yiming, Kaffenberger, Benjamin, Yang, Carrie, Towns, William H., Lehman, Amy, Johnson, Amy J., Muthusamy, Natarajan, Devine, Steven M., Jaglowski, Samantha, Serody, Jonathan S., Murphy, William J., Munn, David H., Luznik, Leo, Hill, Geoffrey R., Wong, Henry K., MacDonald, Kelli K.P., Maillard, Ivan, Koreth, John, Elias, Laurence, Cutler, Corey, Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Panoskaltsis-Mortari, Angela, Byrd, John C., Blazar, Bruce R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347242/
https://ncbi.nlm.nih.gov/pubmed/25271622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75328
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