Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

T-cell activation releases inositol 1,4,5-trisphosphate (IP(3)), inducing cytoplasmic calcium (Ca(2+)) influx. In turn, inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) phosphorylates IP(3) to negatively regulate and thereby tightly control Ca(2+) fluxes that are essential for mature T-cell activatio...

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Published in:Blood
Main Authors: Thangavelu, Govindarajan, Du, Jing, Paz, Katelyn G., Loschi, Michael, Zaiken, Michael C., Flynn, Ryan, Taylor, Patricia A., Kirchmeier, Andrew Kemal, Panoskaltsis-Mortari, Angela, Luznik, Leo, MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Munn, David H., Serody, Jonathan S., Murphy, William J., Miklos, David, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Dahlberg, Carol, Miller, Andrew T., Blazar, Bruce R.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Immunobiology and Immunotherapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940197/
https://ncbi.nlm.nih.gov/pubmed/31697815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000032
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