Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

T-cell activation releases inositol 1,4,5-trisphosphate (IP(3)), inducing cytoplasmic calcium (Ca(2+)) influx. In turn, inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) phosphorylates IP(3) to negatively regulate and thereby tightly control Ca(2+) fluxes that are essential for mature T-cell activatio...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Thangavelu, Govindarajan, Du, Jing, Paz, Katelyn G., Loschi, Michael, Zaiken, Michael C., Flynn, Ryan, Taylor, Patricia A., Kirchmeier, Andrew Kemal, Panoskaltsis-Mortari, Angela, Luznik, Leo, MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Munn, David H., Serody, Jonathan S., Murphy, William J., Miklos, David, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Dahlberg, Carol, Miller, Andrew T., Blazar, Bruce R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2020
Konular:
Immunobiology and Immunotherapy
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940197/
https://ncbi.nlm.nih.gov/pubmed/31697815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000032
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