Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

T-cell activation releases inositol 1,4,5-trisphosphate (IP(3)), inducing cytoplasmic calcium (Ca(2+)) influx. In turn, inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) phosphorylates IP(3) to negatively regulate and thereby tightly control Ca(2+) fluxes that are essential for mature T-cell activatio...

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Foilsithe in:Blood
Main Authors: Thangavelu, Govindarajan, Du, Jing, Paz, Katelyn G., Loschi, Michael, Zaiken, Michael C., Flynn, Ryan, Taylor, Patricia A., Kirchmeier, Andrew Kemal, Panoskaltsis-Mortari, Angela, Luznik, Leo, MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Munn, David H., Serody, Jonathan S., Murphy, William J., Miklos, David, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Dahlberg, Carol, Miller, Andrew T., Blazar, Bruce R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2020
Ábhair:
Immunobiology and Immunotherapy
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940197/
https://ncbi.nlm.nih.gov/pubmed/31697815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000032
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