Targeting PI3Kδ Function For Amelioration of Murine Chronic Graft-Versus-Host Disease

Chronic graft-versus-host disease is a leading cause of morbidity and mortality following allotransplant. Activated donor effector T-cells can differentiate into pathogenic T helper (Th)-17 cells and germinal center-promoting Tfollicular helper cells, resulting in cGVHD. Phosphoinositide-3-kinase-δ,...

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izdano v:Am J Transplant
Main Authors: Paz, Katelyn, Flynn, Ryan, Du, Jing, Tannheimer, Stacey, Johnson, Amy J., Dong, Shuai, Stark, Anne-Katrien, Okkenhaug, Klaus, Panoskaltsis-Mortari, Angela, Sage, Peter T., Sharpe, Arlene H., Luznik, Leo, Ritz, Jerome, Soiffer, Robert J., Cutler, Corey S., Koreth, John, Antin, Joseph H., Miklos, David B., MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Serody, Jonathan S., Murphy, William J., Munn, David H., Feser, Colby, Zaiken, Michael, Vanhaesebroeck, Bart, Turka, Laurence A., Byrd, John C., Blazar, Bruce R.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538456/
https://ncbi.nlm.nih.gov/pubmed/30748099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.15305
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