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Cytokines reinstate NK cell–mediated cancer immunosurveillance

In healthy individuals, cells that lose expression of MHC class I molecules are quickly targeted for elimination by NK lymphocytes. A paradox in cancer immunology is the observation that many tumor cells often have a drastic reduction of MHC class I molecules, yet these cells are not eliminated by N...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zitvogel, Laurence, Kroemer, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347239/
https://ncbi.nlm.nih.gov/pubmed/25329691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78531
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