IER3 supports KRAS(G12D)-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation

Activating mutations in the KRAS oncogene are prevalent in pancreatic ductal adenocarcinoma (PDAC). We previously demonstrated that pancreatic intraepithelial neoplasia (PanIN) formation, which precedes malignant transformation, associates with the expression of immediate early response 3 (Ier3) as...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Garcia, Maria Noé, Grasso, Daniel, Lopez-Millan, Maria Belen, Hamidi, Tewfik, Loncle, Celine, Tomasini, Richard, Lomberk, Gwen, Porteu, Françoise, Urrutia, Raul, Iovanna, Juan L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347237/
https://ncbi.nlm.nih.gov/pubmed/25250570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76037
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