IER3 supports KRAS(G12D)-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation

Activating mutations in the KRAS oncogene are prevalent in pancreatic ductal adenocarcinoma (PDAC). We previously demonstrated that pancreatic intraepithelial neoplasia (PanIN) formation, which precedes malignant transformation, associates with the expression of immediate early response 3 (Ier3) as...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Garcia, Maria Noé, Grasso, Daniel, Lopez-Millan, Maria Belen, Hamidi, Tewfik, Loncle, Celine, Tomasini, Richard, Lomberk, Gwen, Porteu, Françoise, Urrutia, Raul, Iovanna, Juan L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347237/
https://ncbi.nlm.nih.gov/pubmed/25250570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76037
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