Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence

Nuclear protein 1 (Nupr1), a small chromatin protein, has a critical role in cancer development, progression and resistance to therapy. Previously, we had demonstrated that Nupr1 cooperates with Kras(G12D) to induce pancreas intraepithelial neoplasias (PanIN) formation and pancreatic ductal adenocar...

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Autori principali: Grasso, D, Garcia, M N, Hamidi, T, Cano, C, Calvo, E, Lomberk, G, Urrutia, R, Iovanna, J L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158688/
https://ncbi.nlm.nih.gov/pubmed/24902898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.74
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