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Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation
Nupr1 is a chromatin protein, which cooperates with Kras(G12D) to induce PanIN formation and pancreatic cancer development in mice, though the molecular mechanisms underlying this effect remain to be fully characterized. In the current study, we report that Nupr1 acts as a gene modifier of the effec...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4663475/ https://ncbi.nlm.nih.gov/pubmed/26617245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17549 |
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