RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

Osteoclastogenesis requires activation of RANK signaling as well as costimulatory signals from immunoreceptor tyrosine-based activation motif-containing (ITAM-containing) receptors/adaptors, predominantly tyrosine kinase–binding proteins DAP12 and FcRγ, in osteoclast precursors. It is not well under...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Li, Susan, Miller, Christine H., Giannopoulou, Eugenia, Hu, Xiaoyu, Ivashkiv, Lionel B., Zhao, Baohong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347236/
https://ncbi.nlm.nih.gov/pubmed/25329696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71882
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