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RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes

Development of alternatively activated (M2) macrophage phenotypes is a complex process that is coordinately regulated by a plethora of pathways and factors. Here, we report that RBP-J, a DNA-binding protein that integrates signals from multiple pathways including the Notch pathway, is critically inv...

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Pubblicato in:Protein Cell
Autori principali: Foldi, Julia, Shang, Yingli, Zhao, Baohong, Ivashkiv, Lionel B., Hu, Xiaoyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Higher Education Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791428/
https://ncbi.nlm.nih.gov/pubmed/26874522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-016-0248-7
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