Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination

The signal-responsive E3 ubiquitin ligase pellino 1 (PELI1) regulates TLR and T cell receptor (TCR) signaling and contributes to the maintenance of autoimmunity; however, little is known about the consequence of mutations that result in upregulation of PELI1. Here, we developed transgenic mice that...

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Publicado en:J Clin Invest
Autores principales: Park, Hye-Young, Go, Heounjeong, Song, Ha Rim, Kim, Suhyeon, Ha, Geun-Hyoung, Jeon, Yoon-Kyung, Kim, Ji-Eun, Lee, Ho, Cho, Hyeseong, Kang, Ho Chul, Chung, Hee-Young, Kim, Chul-Woo, Chung, Doo Hyun, Lee, Chang-Woo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347227/
https://ncbi.nlm.nih.gov/pubmed/25295537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75667
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