Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications

There is strong evidence that overproduction of soluble fms-like tyrosine kinase-1 (sFLT1) in the placenta is a major cause of vascular dysfunction in preeclampsia through sFLT1-dependent antagonism of VEGF. However, the cause of placental sFLT1 upregulation is not known. Here we demonstrated that i...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Fan, Xiujun, Rai, Anshita, Kambham, Neeraja, Sung, Joyce F., Singh, Nirbhai, Petitt, Matthew, Dhal, Sabita, Agrawal, Rani, Sutton, Richard E., Druzin, Maurice L., Gambhir, Sanjiv S., Ambati, Balamurali K., Cross, James C., Nayak, Nihar R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347223/
https://ncbi.nlm.nih.gov/pubmed/25329693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76864
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