Collaborative rewiring of the pluripotency network by chromatin and signalling modulating pathways

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) represents a profound change in cell fate. Here, we show that combining ascorbic acid (AA) and 2i (MAP kinase and GSK inhibitors) increases the efficiency of reprogramming from fibroblasts and synergistically enhances conversio...

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Publicat a:Nat Commun
Autors principals: Tran, Khoa A., Jackson, Steven A., Olufs, Zachariah P.G., Zaidan, Nur Zafirah, Leng, Ning, Kendziorski, Christina, Roy, Sushmita, Sridharan, Rupa
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347202/
https://ncbi.nlm.nih.gov/pubmed/25650115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7188
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