Collaborative rewiring of the pluripotency network by chromatin and signalling modulating pathways

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) represents a profound change in cell fate. Here, we show that combining ascorbic acid (AA) and 2i (MAP kinase and GSK inhibitors) increases the efficiency of reprogramming from fibroblasts and synergistically enhances conversio...

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Vydáno v:Nat Commun
Hlavní autoři: Tran, Khoa A., Jackson, Steven A., Olufs, Zachariah P.G., Zaidan, Nur Zafirah, Leng, Ning, Kendziorski, Christina, Roy, Sushmita, Sridharan, Rupa
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347202/
https://ncbi.nlm.nih.gov/pubmed/25650115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7188
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