Collaborative rewiring of the pluripotency network by chromatin and signalling modulating pathways

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) represents a profound change in cell fate. Here, we show that combining ascorbic acid (AA) and 2i (MAP kinase and GSK inhibitors) increases the efficiency of reprogramming from fibroblasts and synergistically enhances conversio...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tran, Khoa A., Jackson, Steven A., Olufs, Zachariah P.G., Zaidan, Nur Zafirah, Leng, Ning, Kendziorski, Christina, Roy, Sushmita, Sridharan, Rupa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347202/
https://ncbi.nlm.nih.gov/pubmed/25650115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7188
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