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NH(2)-terminal truncations of cardiac troponin I and cardiac troponin T produce distinct effects on contractility and calcium homeostasis in adult cardiomyocytes

Cardiac troponin I (TnI) has an NH(2)-terminal extension that is an adult heart-specific regulatory structure. Restrictive proteolytic truncation of the NH(2)-terminal extension of cardiac TnI occurs in normal hearts and is upregulated in cardiac adaptation to hemodynamic stress or β-adrenergic defi...

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Опубликовано в: :Am J Physiol Cell Physiol
Главные авторы: Wei, Hongguang, Jin, J.-P.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346733/
https://ncbi.nlm.nih.gov/pubmed/25518962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00358.2014
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