In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.

Recently, it has been reported that the protein kinase C (PKC) beta isoform plays a critical role in the development of hypertrophy and heart failure. The purpose of the present study was to clarify the mechanism by which activation of PKCbeta led to depressed cardiac function. Thus, we used a PKCbe...

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Hlavní autoři: Takeishi, Y, Chu, G, Kirkpatrick, D M, Li, Z, Wakasaki, H, Kranias, E G, King, G L, Walsh, R A
Médium: Artigo
Jazyk:Inglês
Vydáno: 1998
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC509067/
https://ncbi.nlm.nih.gov/pubmed/9649559
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