In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.

Recently, it has been reported that the protein kinase C (PKC) beta isoform plays a critical role in the development of hypertrophy and heart failure. The purpose of the present study was to clarify the mechanism by which activation of PKCbeta led to depressed cardiac function. Thus, we used a PKCbe...

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Detalhes bibliográficos
Main Authors: Takeishi, Y, Chu, G, Kirkpatrick, D M, Li, Z, Wakasaki, H, Kranias, E G, King, G L, Walsh, R A
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC509067/
https://ncbi.nlm.nih.gov/pubmed/9649559
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