In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.

Recently, it has been reported that the protein kinase C (PKC) beta isoform plays a critical role in the development of hypertrophy and heart failure. The purpose of the present study was to clarify the mechanism by which activation of PKCbeta led to depressed cardiac function. Thus, we used a PKCbe...

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Bibliografiske detaljer
Main Authors: Takeishi, Y, Chu, G, Kirkpatrick, D M, Li, Z, Wakasaki, H, Kranias, E G, King, G L, Walsh, R A
Format: Artigo
Sprog:Inglês
Udgivet: 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC509067/
https://ncbi.nlm.nih.gov/pubmed/9649559
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