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NH(2)-terminal truncations of cardiac troponin I and cardiac troponin T produce distinct effects on contractility and calcium homeostasis in adult cardiomyocytes
Cardiac troponin I (TnI) has an NH(2)-terminal extension that is an adult heart-specific regulatory structure. Restrictive proteolytic truncation of the NH(2)-terminal extension of cardiac TnI occurs in normal hearts and is upregulated in cardiac adaptation to hemodynamic stress or β-adrenergic defi...
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| Veröffentlicht in: | Am J Physiol Cell Physiol |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4346733/ https://ncbi.nlm.nih.gov/pubmed/25518962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00358.2014 |
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