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The heart-specific NH(2)-terminal extension regulates the molecular conformation and function of cardiac troponin I

In addition to the core structure conserved in all troponin I isoforms, cardiac troponin I (cTnI) has an ∼30 amino acids NH(2)-terminal extension. This peptide segment is a heart-specific regulatory structure containing two Ser residues that are substrates of PKA. Under β-adrenergic regulation, phos...

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Detalhes bibliográficos
Main Authors: Akhter, Shirin, Zhang, Zhiling, Jin, J.-P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322736/
https://ncbi.nlm.nih.gov/pubmed/22140044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00637.2011
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