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The heart-specific NH(2)-terminal extension regulates the molecular conformation and function of cardiac troponin I
In addition to the core structure conserved in all troponin I isoforms, cardiac troponin I (cTnI) has an ∼30 amino acids NH(2)-terminal extension. This peptide segment is a heart-specific regulatory structure containing two Ser residues that are substrates of PKA. Under β-adrenergic regulation, phos...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Physiological Society
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3322736/ https://ncbi.nlm.nih.gov/pubmed/22140044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00637.2011 |
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