Cargando...
Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T
The α-helix in troponin I (TnI) at the interface with troponin T (TnT) is a highly conserved structure. A point mutation in this region, A116G, was found in human cardiac TnI in a case of cardiomyopathy. An adjacent dominantly negative mutation found in turkey cardiac TnI (R111C, equivalent to K117C...
Gardado en:
| Publicado en: | FEBS Open Bio |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2015
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4325132/ https://ncbi.nlm.nih.gov/pubmed/25685665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.01.001 |
| Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|