Impaired Phagocytosis of Apoptotic Cells by Macrophages in Chronic Granulomatous Disease Is Reversed by IFN-γ in a Nitric Oxide-Dependent Manner

Immunodeficiency in chronic granulomatous disease (CGD) is well characterized. Less understood are exaggerated sterile inflammation and autoimmunity associated with CGD. Impaired recognition and clearance of apoptotic cells resulting in their disintegration may contribute to CGD inflammation. We hyp...

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Publicado en:J Immunol
Main Authors: Fernandez-Boyanapalli, Ruby, McPhillips, Kathleen A., Frasch, S. Courtney, Janssen, William J., Dinauer, Mary C., Riches, David W. H., Henson, Peter M., Byrne, Aideen, Bratton, Donna L.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346245/
https://ncbi.nlm.nih.gov/pubmed/20805415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001778
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