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Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in Chronic Granulomatous Disease
BACKGROUND: Deficient production of reactive oxygen species (ROS) by the phagocyte NADPH oxidase in Chronic Granulomatous Disease (CGD) results in susceptibility to certain pathogens secondary to impaired oxidative killing and mobilization of other phagocyte defenses. PPARγ agonists including piogli...
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Publicado no: | J Allergy Clin Immunol |
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Main Authors: | , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331116/ https://ncbi.nlm.nih.gov/pubmed/25498313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.10.034 |
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