Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in Chronic Granulomatous Disease

BACKGROUND: Deficient production of reactive oxygen species (ROS) by the phagocyte NADPH oxidase in Chronic Granulomatous Disease (CGD) results in susceptibility to certain pathogens secondary to impaired oxidative killing and mobilization of other phagocyte defenses. PPARγ agonists including piogli...

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Publicado en:J Allergy Clin Immunol
Autores principales: Fernandez-Boyanapalli, Ruby F., Frasch, S. Courtney, Thomas, Stacey M., Malcolm, Kenneth C., Nicks, Michael, Harbeck, Ronald J., Jakubzick, Claudia V., Nemenoff, Raphael, Henson, Peter M., Holland, Steven M., Bratton, Donna L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331116/
https://ncbi.nlm.nih.gov/pubmed/25498313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.10.034
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