Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.

A subtle mutation that rendered type I collagen resistant to mammalian collagenase has been introduced into the murine Col1a-1 (recently redesignated Cola-1) gene by homologous recombination in embryonic stem (ES) cells. Initially, a "hit and run" procedure was used. Since two steps were r...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Wu, H, Liu, X, Jaenisch, R
Format: Artigo
Jezik:Inglês
Izdano: 1994
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC43462/
https://ncbi.nlm.nih.gov/pubmed/8146196
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki