Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

Since its discovery and isolation, exogenous insulin has dramatically changed the outlook for patients with diabetes. However, even when patients strictly follow an insulin regimen, serious complications can result as patients experience both hyperglycemic and hypoglycemic states. Several chemically...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Chou, Danny Hung-Chieh, Webber, Matthew J., Tang, Benjamin C., Lin, Amy B., Thapa, Lavanya S., Deng, David, Truong, Jonathan V., Cortinas, Abel B., Langer, Robert, Anderson, Daniel G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345600/
https://ncbi.nlm.nih.gov/pubmed/25675515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424684112
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