Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

Since its discovery and isolation, exogenous insulin has dramatically changed the outlook for patients with diabetes. However, even when patients strictly follow an insulin regimen, serious complications can result as patients experience both hyperglycemic and hypoglycemic states. Several chemically...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Chou, Danny Hung-Chieh, Webber, Matthew J., Tang, Benjamin C., Lin, Amy B., Thapa, Lavanya S., Deng, David, Truong, Jonathan V., Cortinas, Abel B., Langer, Robert, Anderson, Daniel G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345600/
https://ncbi.nlm.nih.gov/pubmed/25675515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424684112
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