Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

Since its discovery and isolation, exogenous insulin has dramatically changed the outlook for patients with diabetes. However, even when patients strictly follow an insulin regimen, serious complications can result as patients experience both hyperglycemic and hypoglycemic states. Several chemically...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Chou, Danny Hung-Chieh, Webber, Matthew J., Tang, Benjamin C., Lin, Amy B., Thapa, Lavanya S., Deng, David, Truong, Jonathan V., Cortinas, Abel B., Langer, Robert, Anderson, Daniel G.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345600/
https://ncbi.nlm.nih.gov/pubmed/25675515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424684112
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