Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

Since its discovery and isolation, exogenous insulin has dramatically changed the outlook for patients with diabetes. However, even when patients strictly follow an insulin regimen, serious complications can result as patients experience both hyperglycemic and hypoglycemic states. Several chemically...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chou, Danny Hung-Chieh, Webber, Matthew J., Tang, Benjamin C., Lin, Amy B., Thapa, Lavanya S., Deng, David, Truong, Jonathan V., Cortinas, Abel B., Langer, Robert, Anderson, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345600/
https://ncbi.nlm.nih.gov/pubmed/25675515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424684112
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