Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

Inducible nitric oxide synthase (iNOS) is a key enzyme in the macrophage inflammatory response, which is the source of nitric oxide (NO) that is potently induced in response to proinflammatory stimuli. However, the specific role of NO production, as distinct from iNOS induction, in macrophage inflam...

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Bibliografiske detaljer
Udgivet i:Free Radic Biol Med
Main Authors: McNeill, Eileen, Crabtree, Mark J., Sahgal, Natasha, Patel, Jyoti, Chuaiphichai, Surawee, Iqbal, Asif J., Hale, Ashley B., Greaves, David R., Channon, Keith M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science 2015
Fag:
Original Contribution
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344222/
https://ncbi.nlm.nih.gov/pubmed/25451639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.10.575
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