Regulatory iNKT cells lack PLZF expression and control T(reg) cell and macrophage homeostasis in adipose tissue

iNKT cells are CD1d-restricted lipid-sensing innate T cells that express the transcription factor PLZF. iNKT cells accumulate in adipose tissue, where they are anti-inflammatory, but the factors that contribute to their anti-inflammatory nature, and their targets in adipose tissue are unknown. Here...

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Pubblicato in:Nat Immunol
Autori principali: Lynch, Lydia, Michelet, Xavier, Zhang, Sai, Brennan, Patrick J., Moseman, Ashley, Lester, Chantel, Besra, Gurdyal, Vomhof-Dekrey, Emilie E., Tighe, Mike, Koay, Hui-Fern, Godfrey, Dale I., Leadbetter, Elizabeth A., Sant’Angelo, Derek B., von Andrian, Ulrich, Brenner, Michael B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343194/
https://ncbi.nlm.nih.gov/pubmed/25436972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3047
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