Notch1 phenotype and clinical stage progression in non-small cell lung cancer

BACKGROUND: Notch1 transmembrane receptor is activated through ligand-binding- triggered proteolytic cleavages and, upon release, the intracellular domain (N1-ICD) translocates into the nucleus and modulates target gene transcriptions. Notch activation has been implicated in tumorigenesis in an incr...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Nguyen, Dat, Rubinstein, Larry, Takebe, Naoko, Miele, Lucio, Tomaszewski, Joseph E, Ivy, Percy, Doroshow, James H, Yang, Sherry X
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343190/
https://ncbi.nlm.nih.gov/pubmed/25653136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-014-0104-2
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