Notch1 phenotype and clinical stage progression in non-small cell lung cancer

BACKGROUND: Notch1 transmembrane receptor is activated through ligand-binding- triggered proteolytic cleavages and, upon release, the intracellular domain (N1-ICD) translocates into the nucleus and modulates target gene transcriptions. Notch activation has been implicated in tumorigenesis in an incr...

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Bibliographic Details
Published in:J Hematol Oncol
Main Authors: Nguyen, Dat, Rubinstein, Larry, Takebe, Naoko, Miele, Lucio, Tomaszewski, Joseph E, Ivy, Percy, Doroshow, James H, Yang, Sherry X
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343190/
https://ncbi.nlm.nih.gov/pubmed/25653136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-014-0104-2
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