Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells

Uracil in the genome can result from misincorporation of dUTP instead of dTTP during DNA synthesis, and is primarily removed by uracil DNA glycosylase (UNG) during base excision repair. Telomeres contain long arrays of TTAGGG repeats and may be susceptible to uracil misincorporation. Using model tel...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Vallabhaneni, Haritha, Zhou, Fang, Maul, Robert W., Sarkar, Jaya, Yin, Jinhu, Lei, Ming, Harrington, Lea, Gearhart, Patricia J., Liu, Yie
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
DNA and Chromosomes
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342465/
https://ncbi.nlm.nih.gov/pubmed/25572391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607101
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