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Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells
Uracil in the genome can result from misincorporation of dUTP instead of dTTP during DNA synthesis, and is primarily removed by uracil DNA glycosylase (UNG) during base excision repair. Telomeres contain long arrays of TTAGGG repeats and may be susceptible to uracil misincorporation. Using model tel...
Shranjeno v:
| izdano v: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4342465/ https://ncbi.nlm.nih.gov/pubmed/25572391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607101 |
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