Diazaborine Treatment of Yeast Cells Inhibits Maturation of the 60S Ribosomal Subunit

Diazaborine treatment of yeast cells was shown previously to cause accumulation of aberrant, 3′-elongated mRNAs. Here we demonstrate that the drug inhibits maturation of rRNAs for the large ribosomal subunit. Pulse-chase analyses showed that the processing of the 27S pre-rRNA to consecutive species...

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Main Authors: Pertschy, Brigitte, Zisser, Gertrude, Schein, Hermine, Köffel, René, Rauch, Gernot, Grillitsch, Karlheinz, Morgenstern, Christina, Durchschlag, Michael, Högenauer, Gregor, Bergler, Helmut
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC434233/
https://ncbi.nlm.nih.gov/pubmed/15226447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.14.6476-6487.2004
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