Cloning of S-Adenosyl-l-Methionine:C-24-Δ-Sterol-Methyltransferase (ERG6) from Leishmania donovani and Characterization of mRNAs in Wild-Type and Amphotericin B-Resistant Promastigotes

The 24-alkylated sterols have been shown previously to be absent in membranes of amphotericin B (AmB)-resistant Leishmania donovani promastigotes, suggesting that the S- adenosyl-l-methionine:C-24-Δ-sterol-methyltransferase (SCMT or ERG6) was not functional or not expressed in AmB-resistant (AmB-R)...

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Detalhes bibliográficos
Main Authors: Pourshafie, Mohammad, Morand, Stanislas, Virion, Alain, Rakotomanga, Michaelle, Dupuy, Corinne, Loiseau, Philippe M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC434211/
https://ncbi.nlm.nih.gov/pubmed/15215088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.7.2409-2414.2004
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