Miltefosine Affects Lipid Metabolism in Leishmania donovani Promastigotes

Miltefosine (hexadecylphosphocholine [HePC]) is the first orally active antileishmanial drug. Transient HePC treatment of Leishmania donovani promastigotes at 10 μM significantly reduced the phosphatidylcholine content and enhanced the phosphatidylethanolamine (PE) content in parasite membranes, sug...

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Bibliographic Details
Main Authors: Rakotomanga, M., Blanc, S., Gaudin, K., Chaminade, P., Loiseau, P. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855451/
https://ncbi.nlm.nih.gov/pubmed/17242145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01123-06
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