Alteration of Fatty Acid and Sterol Metabolism in Miltefosine-Resistant Leishmania donovani Promastigotes and Consequences for Drug-Membrane Interactions

Miltefosine (hexadecylphosphocholine [HePC]) is the first orally active drug approved for the treatment of visceral leishmaniasis. In order to investigate the biochemical modifications occurring in HePC-resistant (HePC-R) Leishmania donovani promastigotes, taking into account the lipid nature of HeP...

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Bibliografiske detaljer
Main Authors: Rakotomanga, M., Saint-Pierre-Chazalet, M., Loiseau, P. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168669/
https://ncbi.nlm.nih.gov/pubmed/15980336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.7.2677-2686.2005
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