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Alteration of Fatty Acid and Sterol Metabolism in Miltefosine-Resistant Leishmania donovani Promastigotes and Consequences for Drug-Membrane Interactions
Miltefosine (hexadecylphosphocholine [HePC]) is the first orally active drug approved for the treatment of visceral leishmaniasis. In order to investigate the biochemical modifications occurring in HePC-resistant (HePC-R) Leishmania donovani promastigotes, taking into account the lipid nature of HeP...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2005
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1168669/ https://ncbi.nlm.nih.gov/pubmed/15980336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.7.2677-2686.2005 |
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