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Absorption of Ester Prodrugs in Caco-2 and Rat Intestine Models

The aim of this study was to elucidate the absorption mechanism in Caco-2 and rat intestine models in order to improve the accuracy of prediction of oral absorption of ester prodrugs. Pivampicillin and cefcapene pivoxil hydrochloride (CFPN-PI), ester-type oral antibiotics, were chosen as model ester...

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Detalhes bibliográficos
Main Authors: He, Xin, Sugawara, Mitsuru, Takekuma, Yoh, Miyazaki, Katsumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC434205/
https://ncbi.nlm.nih.gov/pubmed/15215116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.7.2604-2609.2004
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