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Intestinal Absorption of Novel-Dipeptide Prodrugs of Saquinavir in Rats
Saquinavir (SQV) was the first human immuno-virus-1 (HIV-1) protease inhibitor approved by FDA. However, P-glycoprotein (P-gp), an efflux pump limits its oral and brain bioavailabilities. The objective of this study is to investigate whether prodrug modification of SQV to dipeptide prodrugs Valine-V...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3166959/ https://ncbi.nlm.nih.gov/pubmed/17207946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2006.11.058 |
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