Chargement en cours...
Intestinal Absorption of Novel-Dipeptide Prodrugs of Saquinavir in Rats
Saquinavir (SQV) was the first human immuno-virus-1 (HIV-1) protease inhibitor approved by FDA. However, P-glycoprotein (P-gp), an efflux pump limits its oral and brain bioavailabilities. The objective of this study is to investigate whether prodrug modification of SQV to dipeptide prodrugs Valine-V...
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3166959/ https://ncbi.nlm.nih.gov/pubmed/17207946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2006.11.058 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|