Dihydropteroate Synthase Mutations in Pneumocystis jiroveci Can Affect Sulfamethoxazole Resistance in a Saccharomyces cerevisiae Model

Dihydropteroate synthase (DHPS) mutations in Pneumocystis jiroveci have been associated epidemiologically with resistance to sulfamethoxazole (SMX). Since P. jiroveci cannot be cultured, inherent drug resistance cannot be measured. This study explores the effects of these mutations in a tractable mo...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Iliades, Peter, Meshnick, Steven R., Macreadie, Ian G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2004
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434176/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215118/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2617-2623.2004
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