Dihydropteroate Synthase Mutations in Pneumocystis jiroveci Can Affect Sulfamethoxazole Resistance in a Saccharomyces cerevisiae Model

Dihydropteroate synthase (DHPS) mutations in Pneumocystis jiroveci have been associated epidemiologically with resistance to sulfamethoxazole (SMX). Since P. jiroveci cannot be cultured, inherent drug resistance cannot be measured. This study explores the effects of these mutations in a tractable mo...

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Bibliographische Detailangaben
Hauptverfasser: Iliades, Peter, Meshnick, Steven R., Macreadie, Ian G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC434176/
https://ncbi.nlm.nih.gov/pubmed/15215118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.7.2617-2623.2004
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