Dihydropteroate Synthase Mutations in Pneumocystis jiroveci Can Affect Sulfamethoxazole Resistance in a Saccharomyces cerevisiae Model

Dihydropteroate synthase (DHPS) mutations in Pneumocystis jiroveci have been associated epidemiologically with resistance to sulfamethoxazole (SMX). Since P. jiroveci cannot be cultured, inherent drug resistance cannot be measured. This study explores the effects of these mutations in a tractable mo...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Iliades, Peter, Meshnick, Steven R., Macreadie, Ian G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2004
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434176/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215118/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2617-2623.2004
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