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Dihydropteroate Synthase Mutations in Pneumocystis jiroveci Can Affect Sulfamethoxazole Resistance in a Saccharomyces cerevisiae Model

Dihydropteroate synthase (DHPS) mutations in Pneumocystis jiroveci have been associated epidemiologically with resistance to sulfamethoxazole (SMX). Since P. jiroveci cannot be cultured, inherent drug resistance cannot be measured. This study explores the effects of these mutations in a tractable mo...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Iliades, Peter, Meshnick, Steven R., Macreadie, Ian G.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2004
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434176/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215118/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2617-2623.2004
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