Dihydropteroate Synthase Mutations in Pneumocystis jiroveci Can Affect Sulfamethoxazole Resistance in a Saccharomyces cerevisiae Model

Dihydropteroate synthase (DHPS) mutations in Pneumocystis jiroveci have been associated epidemiologically with resistance to sulfamethoxazole (SMX). Since P. jiroveci cannot be cultured, inherent drug resistance cannot be measured. This study explores the effects of these mutations in a tractable mo...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Iliades, Peter, Meshnick, Steven R., Macreadie, Ian G.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2004
Témata:	Mechanisms of Resistance
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434176/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215118/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2617-2623.2004
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