Pneumocystis jiroveci Dihydropteroate Synthase Polymorphisms Confer Resistance to Sulfadoxine and Sulfanilamide in Saccharomyces cerevisiae

Failure of anti-Pneumocystis jiroveci prophylaxis with sulfa drugs is associated with mutations within the putative active site of the fungal dihydropteroate synthase (DHPS), an enzyme encoded by the multidomain FAS gene. This enzyme is involved in the essential biosynthesis of folic acid. The most...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Meneau, I., Sanglard, D., Bille, J., Hauser, P. M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2004
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434158/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215117/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2610-2616.2004
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