Pneumocystis jiroveci Dihydropteroate Synthase Polymorphisms Confer Resistance to Sulfadoxine and Sulfanilamide in Saccharomyces cerevisiae

Failure of anti-Pneumocystis jiroveci prophylaxis with sulfa drugs is associated with mutations within the putative active site of the fungal dihydropteroate synthase (DHPS), an enzyme encoded by the multidomain FAS gene. This enzyme is involved in the essential biosynthesis of folic acid. The most...

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Bibliografski detalji

Izdano u:	Antimicrob Agents Chemother
Glavni autori:	Meneau, I., Sanglard, D., Bille, J., Hauser, P. M.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2004
Teme:	Mechanisms of Resistance
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434158/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215117/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2610-2616.2004
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