Pneumocystis jiroveci Dihydropteroate Synthase Polymorphisms Confer Resistance to Sulfadoxine and Sulfanilamide in Saccharomyces cerevisiae

Failure of anti-Pneumocystis jiroveci prophylaxis with sulfa drugs is associated with mutations within the putative active site of the fungal dihydropteroate synthase (DHPS), an enzyme encoded by the multidomain FAS gene. This enzyme is involved in the essential biosynthesis of folic acid. The most...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Meneau, I., Sanglard, D., Bille, J., Hauser, P. M.
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2004
Matèries:	Mechanisms of Resistance
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434158/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215117/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2610-2616.2004
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