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Mutual Antagonism of Wilms’ Tumor 1 and β-Catenin Dictates Podocyte Health and Disease

Activation of β-catenin, the intracellular mediator of canonical Wnt signaling, has a critical role in mediating podocyte injury and proteinuria. However, the underlying mechanisms remain poorly understood. Here, we show that β-catenin triggers ubiquitin-mediated protein degradation of Wilms’ tumor...

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發表在:J Am Soc Nephrol
Main Authors: Zhou, Lili, Li, Yingjian, He, Weichun, Zhou, Dong, Tan, Roderick J., Nie, Jing, Hou, Fan Fan, Liu, Youhua
格式: Artigo
語言:Inglês
出版: American Society of Nephrology 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341470/
https://ncbi.nlm.nih.gov/pubmed/25071087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013101067
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